Poor efficacy of ranitidine bismuth citrate-based triple therapies for Helicobacter pylori eradication.

نویسندگان

  • Ahmet Uygun
  • Abdurrahman Kadayifci
  • Zeki Yesilova
  • Yuksel Ates
  • Mukerrem Safali
  • Seyfettin Ilgan
  • Sait Bagci
  • Kemal Dagalp
چکیده

BACKGROUND Helicobacter pylori eradication rates have tended to decrease recently possibly related with increasing antibiotic resistance. The present study investigated the efficacy of three different ranitidine bismuth citrate (RBC) based triple regimens in a population with high prevalence of H. pylori. METHODS 300 consecutive H. pylori positive patients with non-ulcer dyspepsia were randomized into three regimens: (1) RBC 400 mg, amoxicillin 1000 mg and tetracycline 500 mg [RBC-AT], (2) RBC 400 mg, amoxicillin 1000 mg and clarithromycin 500 mg [RBC-AC], (3) RBC 400 mg, metronidazole 500 mg and tetracycline 500 mg [RBC-MT]. Tetracycline was given q.i.d, all other drugs were given b.i.d. for 14 days. Gastroscopy and (14)C-Urea breath test (UBT) were performed before enrollment and UBT only was repeated 6 weeks after the end of treatment. RESULTS 274 patients completed the protocols. The overall 'intention to treat' and 'per protocol' H. pylori eradication rates in all subjects were 57.6% (95% CI: 52-63) and 63.1% (95% CI: 57-68), respectively. The eradication rates achieved in the groups (RBC-AT, RBC-AC and RBC-MT) were 64.4% (95% CI: 54-74), 66.2% (95% CI: 56-76), and 58.9% (95% CI: 49-68) on 'per protocol' analyses, respectively. There was no difference in eradication rates, compliance and major side effects between the groups. CONCLUSION The current RBC-based H. pylori eradication therapy is not adequately effective.

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عنوان ژورنال:
  • Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology

دوره 26 4  شماره 

صفحات  -

تاریخ انتشار 2007